All-In with Chamath, Jason, Sacks & Friedberg
Industry veterans, degenerate gamblers & besties Chamath Palihapitiya, Jason Calacanis, David Sacks & David Friedberg cover all things economic, tech, political, social & poker.
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Can We Trust the FDA? Marty Makary on Science, Power & Patients
<p>(0:00) Friedberg intros FDA Commissioner Marty Makary</p> <p>(3:21) Inside the 42 major FDA reforms in 10 months</p> <p>(7:51) The China Race: Winning back biotech leadership</p> <p>(13:14) Accelerating drug approvals safely, how to cut down on clinical trial timelines</p> <p>(33:13) Reshaping the failed Food Pyramid</p> <p>(41:29) GLP-1s and America's Obesity Epidemic</p> <p>(49:54) Rethinking vaccines from first principles</p> <p>(59:40) Lowering drug prices, the power of AI for healthcare</p> <p>(1:18:57) What causes autism?</p> <p>Follow Marty Makary:</p> <p>https://x.com/DrMakaryFDA</p> <p>Follow the besties:</p> <p>https://x.com/chamath</p> <...
Adam Carolla on California's Collapse: Fires, Failed Leadership, and Gyno-Fascism
<p>(0:00) David Friedberg introduces Adam Carolla!</p> <p>(1:32) Palisades Fire one year out: the rebuilding crisis in LA</p> <p>(7:39) Gyno-fascism and safety culture</p> <p>(15:49) Media bias and gender dynamics</p> <p>(28:51) DEI, Hollywood's transformation, socialism, "safe spaces and octagons"</p> <p>(36:14) Is America living through the "Hard times make strong men" adage? Can two Americas coexist?</p> <p>(51:23) Who should be California's next governor?</p> <p>(58:04) Big Tech, AI, and the 2028 Election</p> <p>When you need a partner trusted by millions, there's one platform for all business - PayPal Open.</p> <p>Grow today at https://www...
All-In's 2026 Predictions
<p>(0:00) California exodus, asset seizure tax, Besties to Austin?</p> <p>(12:27) Biggest Political Winner</p> <p>(17:45) Biggest Political Loser</p> <p>(32:15) Biggest Business Winner</p> <p>(40:51) Biggest Business Loser</p> <p>(49:34) Biggest Business Deal</p> <p>(56:15) Most Contrarian Belief</p> <p>(1:03:05) Best Performing Asset</p> <p>(1:08:02) Worst Performing Asset</p> <p>(1:15:17) Most Anticipated Trend</p> <p>(1:21:18) Most Anticipated Media</p> <p>Follow the besties:</p> <p>https://x.com/chamath</p> <p>https://x.com/Jason</p> <p>https://x.com/DavidSacks</p> <p>https://x.com/friedberg</p> <p>Follow on X:</p> <p>https://x.com/theallinpod</p> <...
Howard Lutnick: How America Can Hit 6% GDP Growth in 2026
<p>(0:00) Commerce Secretary Howard Lutnick tells a hilarious Air Force One story</p> <p>(2:24) Chamath intros Secretary Lutnick</p> <p>(7:28) Full scope of the Commerce Department</p> <p>(12:59) How Trump's tariff agenda was planned and executed, how it's going</p> <p>(19:50) US-Japan trade deal, China's chaos-to-prowess strategy</p> <p>(36:54) Why the India deal has not yet happened</p> <p>(43:48) Pharma deals, lowering costs for Americans</p> <p>(53:28) Focus on fraud, immigration, gold cards</p> <p>(1:03:48) GDP: Could we see 5 or 6% growth in 2026?</p> <p>(1:11:49) How the Trump Admin revamped the CHIPS Act, Nvidia deal</p> <p>Follow Secretary Lutnick:</p> <...
Why AI will dwarf every tech revolution before it: robots, manufacturing, AR glasses from CES 2026
<p>(0:00) Guest intros: Jasons introduces Bob Sternfels (McKinsey) and Hemant Taneja (General Catalyst)</p> <p>(2:52) The pace of innovation and why VC's are buying hospitals</p> <p>(9:30) CFOs vs CIOs and unlocking growth</p> <p>(20:46) The job market and why graduates aren't getting hired</p> <p>(27:33) Why education is broken</p> <p>(40:03) Tech time capsule</p> <p>Follow Hemant Taneja:</p> <p>https://x.com/htaneja</p> <p>Follow Bob Sternfels:</p> <p>https://www.linkedin.com/in/bob-sternfels</p> <p>Follow the besties:</p> <p>https://x.com/chamath</p> <p>https://x.com/Jason</p> <p>https://x...
Massive Somali Fraud in Minnesota with Nick Shirley, California Asset Seizure, $20B Groq-Nvidia Deal
<p>(0:00) Bestie intros! Nick Shirley joins the show to discuss his recent investigation on potential daycare fraud in Minnesota</p> <p>(3:32) Nick's background, how he got into investigative reporting and YouTube, independence, finding this story</p> <p>(16:36) Why this fraud story is resonating, why the national press initially avoided it</p> <p>(30:08) Future plans, California, possible Al-Shabaab connection, how high up does Minnesota's fraud go?</p> <p>(49:15) What the scale of fraud means for America, Minnesota's future, potential patronage scheme</p> <p>(1:09:06) CA's wealth tax: normalizing the seizure of private property</p> <p>(1:33:56) Chamath breaks down the $20B Groq-Nvidia deal<...
All-In x Kill Tony: A Hilarious Holiday Special
<p>(0:00) Intro!</p> <p>(2:47) Tony Hinchcliffe roasts the Besties</p> <p>(15:01) Interview: Kill Tony success, MSG rally, origin story, free speech in Europe</p> <p>(36:03) The Besties play Kill Tony!</p> <p>(50:14) The 2025 Bestie Awards: Business, Politics, Tech, and more</p> <p>Thanks to our partners for making this happen!</p> <p>IREN: https://iren.com</p> <p>OKX: https://okx.com</p> <p>Google Cloud: https://cloud.google.com</p> <p>Follow Tony:</p> <p>https://www.youtube.com/@killtony</p> <p>https://x.com/TonyHinchcliffe</p> <p>Follow the besties: </p> <p>https://x.com/chamath</p> <p>h...
Scott Bessent: Fixing the Fed, Tariffs for National Security, Solving Affordability in 2026
<p>(0:00) Treasury Secretary Scott Bessent joins the show</p> <p>(0:55) Recapping 2025 and the state of the economy</p> <p>(3:13) Tariffs: Leverage, legal challenges, implementation</p> <p>(15:20) Affordability: inflation, BLS data, interest rates</p> <p>(23:00) The Fed: biggest mistakes, how we got a 15 year asset bubble, rate cycle, appetite for US debt, Fed Chair candidates</p> <p>(42:44) Focus on Main Street, taking equity stakes in American companies</p> <p>(50:40) Tax cuts, Trump accounts, economic legacy</p> <p>Follow Secretary Bessent:</p> <p>https://x.com/SecScottBessent</p> <p>Referenced in the show:</p> <p>https://www.international-economy.com/TIE_Sp25_Bessent.p...
Bernie Sanders: Stop All AI, China's EUV Breakthrough, Inflation Down, Golden Age in 2026?
<p>(0:00) Bestie intros!</p> <p>(0:19) Bernie Sanders calls for AI datacenter moratorium, how to solve the negative perception of AI</p> <p>(17:15) Anti-AI astroturfing: Is the AI sentiment manufactured by special interests?</p> <p>(32:39) Economy: Unemployment, jobs, inflation, are we primed for a "Golden Age" or not?</p> <p>(51:44) Dog Corner!</p> <p>(59:56) China's major AI breakthrough: lithography, impact on the AI race?</p> <p>(1:19:43) Are the rest of the Besties moving to Texas?</p> <p>Follow the besties:</p> <p>https://x.com/chamath</p> <p>https://x.com/Jason</p> <p>https://x.com/DavidSacks</p> <p>https...
Tucker Carlson: Rise of Nick Fuentes, Paramount vs. Netflix, Anti-AI Sentiment, Hottest Takes
<p>(0:00) Tucker joins the besties!</p> <p>(4:11) Paramount vs Netflix: bidding war over Warner Bros Discovery</p> <p>(25:40) What's behind the rise of Nick Fuentes and America First?</p> <p>(49:13) Understanding the Anti-AI sentiment</p> <p>(1:21:52) Tucker in 20: Venezuela, Midterm issues, fall of Europe, Qatar, Charlie Kirk investigation, leaving NATO, supporting Israel</p> <p>Follow Tucker:</p> <p>https://x.com/TuckerCarlson</p> <p>Check out Battalion Metals:</p> <p>https://battalionmetals.com</p> <p>Follow the besties:</p> <p>https://x.com/chamath</p> <p>https://x.com/Jason</p> <p>https://x.com/DavidSacks</p> <p>https://x...
