The a16z Show
The a16z Show discusses tech and culture trends, news, and the future – especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This show is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes are released every week; visit a16z.com for more details and to sign up for our newsletters and other content as well!
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Can AI Fix Professional Networking? | Inside Cosign
<p>What if finding your next job, co-founder, or collaborator depended less on a resume and more on who is willing to vouch for you? Cosign is building a professional network around those signals, with the longer-term goal of giving AI agents access to the relationship and reputation data that traditional networks keep locked away.</p><p>a16z New Media’s David Booth and Dhruv Gupta join MTS to introduce the Cosign Awards, which recognize standout operators, companies, and products based on nominations from the people who know their work. They also unpack the bigger idea behind Cosign: mapping th...
Why AI Could Turn Small Law Firms Into Billion-Dollar Businesses
<p>What happens when AI makes legal work cheap enough to take cases lawyers couldn't afford to touch before? Eve CEO Jay Madheswaran argues that AI won't just cut costs for law firms. It could expand access to legal representation by making an entirely new class of cases economically viable.</p><p>Jay joins a16z General Partner Alex Rampell to explain how Eve is automating plaintiff law from the first client call through settlement, and why some firms are already using it to increase the number of clients each attorney can manage from roughly 100 to 500.</p><p>They also...
The Startups Rebuilding American Industry | The AD50
<p>America’s defense, energy, manufacturing, and robotics booms are increasingly becoming one story: the rebuilding of the country’s industrial base. This year’s AD50 highlights the companies building across that stack, from critical materials and factories to the systems they ultimately power.</p><p>a16z’s Erin Price-Wright and Connor Love join Elena Burger to unpack what has changed. They discuss how defense demand can help finance manufacturing capacity that ultimately serves much larger commercial markets, why AI is changing the economics of American factories, and how a new generation of founders is applying lessons from SpaceX, Tesla, A...
Mark Cuban’s Plan to Make Healthcare Affordable
<p>Mark Cuban thinks AI could transform healthcare, but it won’t fix opaque prices and broken incentives on its own. His starting point for employers: run every benefits contract through AI and ask where you’re getting ripped off.</p><p>Mark joins a16z General Partner Julie Yoo and Erik Torenberg to discuss what he’s learned building Cost Plus Drugs, why trust is its core product, and how greater transparency could put pressure on healthcare costs.</p><p>They also explore where AI can help, what personalized medicine could look like, how the role of doctors may change...
Reinventing School for the AI Era | Joe Liemandt, Gagan Biyani & Erik Torenberg
<p>What should school look like if AI can help students learn dramatically faster? Alpha School founder Joe Liemandt argues the answer isn’t to fill the extra time with more academics, but to redesign school around the skills traditional classrooms struggle to teach: agency, teamwork, entrepreneurship, communication, and doing hard things.</p><p>Joe joins Erik Torenberg and Horowitz and Andreessen Academy co-founder Gagan Biyani to discuss Alpha’s model, where students spend two hours a day on core academics and the rest developing real-world skills through projects. They explore what that approach can teach higher education, why motivation may...
OpenAI: When AI Agents Use Computers Faster Than You
<p>AI agents are approaching a point where they can use computers faster than expert humans, turning the user interface itself into a universal way for AI to interact with software. OpenAI’s Ari Weinstein and James Sun argue that computer use is now entering its scaling moment, as better models, faster execution, and stronger safety controls make agents practical for more consumer and enterprise work.</p><p>Ari and James join a16z’s Seema Amble and Fabrizio Serafini to explain how computer-using agents are already navigating legacy ERPs, reconciling financial data, handling procurement, and operating software without APIs or c...
The New Startup Playbook | Box CEO Aaron Levie
<p>Can a 10-person startup outperform a company with hundreds of employees? Box CEO Aaron Levie argues AI agents are giving small teams a level of leverage that simply wasn't economically possible before, creating a window for startups to outrun incumbents.</p><p>In this episode of Speedrun Office Hours, Aaron explains why founders are shifting from doing the work themselves to orchestrating agents, and why that puts a new premium on strategy, taste, and knowing exactly what to build. He makes the case that nearly every industry and job function could support specialized AI agents, potentially creating hundreds of...
What It Takes to Win as a Founder | Ben Horowitz
<p>What does it take to build a company when AI is changing the rules this quickly? Ben Horowitz argues that technology may make companies easier to start, but the hardest parts of entrepreneurship, making decisions under uncertainty, building momentum, and managing your own doubts, aren't going away.</p><p>Speedrun's Andrew Chen sits down with Ben to discuss why AI feels different from previous technology shifts, whether billion-dollar companies can be built with tiny teams, and why Ben thinks the application itself may eventually become less important as agents work directly against data.</p><p>They also get into...
Amazon CEO Andy Jassy on Why Amazon Is Investing $220 Billion in AI
<p>Amazon expects to spend roughly $220 billion in CapEx in 2026, yet CEO Andy Jassy says the company is still leaving meaningful AI demand on the table.** He believes the buildout could ultimately help make AWS a $1 trillion annual run-rate business.</p><p>Andy joins a16z co-founder Ben Horowitz and Erik Torenberg to discuss why AI demand is growing so quickly, how Amazon decides how much infrastructure to build, and why lower inference costs could unlock broader enterprise adoption.</p><p>They also discuss how AI is reshaping Amazon itself, from smaller teams building products faster to reimagining Alexa, and...
The Frontier Ideas a16z Wants to Fund | Marc Andreessen, Ben Horowitz & Chris Dixon
<p>a16z is expanding a16z crypto into a16z Frontier, a broader mandate to back founders building at the edges of what's possible. Chris Dixon joins Marc Andreessen, Ben Horowitz, and Erik Torenberg to explain why founders should increasingly ask not “is this too ambitious?” but “is this ambitious enough?” — and how AI could pull decades of technological progress forward across hardware, robotics, entertainment, science, and entirely new forms of media.</p><p>They also explore the coming internet of AI agents, why open source matters as AI becomes more powerful, and why some of the most important companies...
